Statistically 2 Level Factorial by Design Expert: In-vitro Design and Formulation of Levitiracetam Extended Release Tablets

Abstract: Background: Levitiracetam is an antiepileptic medication that falls into the BCS Class I drug classification. It used to treat specific types of seizures in adults and children with epilepsy because its high solubility permeability. Aim: The objective present study evaluate extended release tablets levitiracetam by direct compression using HPMCK100, HPMCK15and Xanthan gum/Ethyl cellulose effect dissolution rate 2 level factorial designs Design expert software. Materials Methods: Expert software designs, three independent components X1: drug: HPMCK 100, X2: HPMC K15 X3: Ethyl cellulose/Xanthan gum was do analysis variance (ANOVA), 3D surface plots, counter optimization, desirability. Fourier-transform infrared spectroscopy investigate drug-excipient compatibility. Results Conclusion: from all diffusion control as indicated linear Higuchi plots. data analyzed Peppas equation exponent (n) found be range 0.76-0.93. Amount levetiracetam prepared formulation F2 formulated employing K100 60 mg, HMPCK15 25 Xanthane mg. In cases formulations F1, F3, F4, F5,F8 Indicates nonfickain F2, F6, F7 super case II transport mechanism. released 100% a 8 hr. fulfill specifications for tablets. results ANOVA dependent variables individual combined 3 factors significant (p< 0.05). design find design, surface, optimization optimized formula did better on desirability (1.0), indicating it good fit. FTIR spectra pure mixture various excipients, indicates no chemical interaction between excipients. Keywords: Extended release, software, Levitiracetam, Direct compression, Drug 8hr.